Publications

Some publications in scientific journals:

• Comparison of the Thrombogenicity of a Bare and Antithrombogenic Coated Flow Diverter in an In Vitro Flow Model.

Lenz-Habijan T, Brodde M, Kehrel BE, Bannewitz C, Gromann K, Bhogal P, Aguilar Perez M, Monstadt H, Henkes H. Cardiovasc Intervent Radiol. 2020 Jan;43(1):140-146. doi: 10.1007/s00270-019-02307-5

• Reversibility of platelet P2Y12 inhibition by platelet supplementation: ex vivo and in vitro comparisons of prasugrel, clopidogrel and ticagrelor.

Bertling A, Fender AC, Schüngel L, Rumpf M, Mergemeier K, Geißler G, Sibrowski W, Kelsch R, Waltenberger J, Jakubowski JA, Kehrel BE. J Thromb Haemost. 2018 Jun;16(6):1089-1098. doi: 10.1111/jth.14014

• Oxidation of C-reactive protein by hypochlorous acid leads to the formation of potent platelet activator.

Boncler M, Kehrel B, Szewczyk R, Stec-Martyna E, Bednarek R, Brodde M, Watala C. Int J Biol Macromol. 2018 Feb;107(Pt B):2701-2714. doi: 10.1016/j.ijbiomac.2017.10.159.

• Components in Plasma-Derived Factor VIII, But Not in Recombinant Factor VIII Downregulate Anti-Inflammatory Surface Marker CD163 in Human Macrophages through Release of CXCL4 (Platelet Factor 4).

Bertling A, Brodde MF, Visser M, Treffon J, Fennen M, Fender AC, Kelsch R, Kehrel BE. Transfus Med Hemother. 2017 Sep;44(5):351-357. doi: 10.1159/000472157.

• Prothrombin and factor X are elevated in multiple sclerosis patients.

Göbel K, Kraft P, Pankratz S, Gross CC, Korsukewitz C, Kwiecien R, Mesters R, Kehrel BE, Wiendl H, Kleinschnitz C, Meuth SG. Ann Neurol. 2016 Dec;80(6):946-951. doi: 10.1002/ana.24807.

• Resolving Thromboinflammation in the Brain After Ischemic Stroke?

Kehrel BE, Fender AC. Circulation. 2016 May 31;133(22):2128-31. doi: 10.1161/CIRCULATIONAHA.116.022858.

• The history of the German platelet meeting and Stan Heptinstall’s contribution to create a “European Platelet Spirit”.

Kehrel BE. Platelets. 2015;26(5):389-91. doi: 10.3109/09537104.2015.1046042.

• First characterization of platelet secretion defect in patients with familial hemophagocytic lymphohistiocytosis type 3 (FHL-3).

Nakamura L, Bertling A, Brodde MF, Zur Stadt U, Schulz AS, Ammann S, Sandrock-Lang K, Beutel K, Zieger B, Kehrel BE. Blood. 2015 Jan 8;125(2):412-4. doi: 10.1182/blood-2014-07-587568.

• Cellular Stress Induced by Plasma-Derived Factor VIII Products.

Brodde M, Müller A, Kehrel B. Transfus Med Hemother. 2014 Apr;41(2):140-4. doi: 10.1159/000357992.

• Neutrophils Turn Plasma Proteins into Weapons against HIV-1.

Speth C, Brodde MF, Hagleitner M, Rambach G, Van Aken H, Dierich M, Kehrel BE. PLoS One. 2013 Jun 26;8(6):e66073. doi: 10.1371/journal.pone.0066073.

• Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases.

Bertling A, Niemann S, Hussain M, Holbrook L, Stanley RG, Brodde MF, Pohl S, Schifferdecker T, Roth J, Jurk K, Müller A, Lahav J, Peters G, Heilmann C, Gibbins JM, Kehrel BE. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1979-90. doi: 10.1161/ATVBAHA.112.246249

• Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa.

Horn M, Bertling A, Brodde MF, Müller A, Roth J, Van Aken H, Jurk K, Heilmann C, Peters G, Kehrel BE. J Thromb Haemost. 2012 Apr;10(4):647-61. doi: 10.1111/j.1538-7836.2012.04640.x.

• Extracellular protein disulfide isomerase regulates feedback activation of platelet thrombin generation via modulation of coagulation factor binding.

Jurk K, Lahav J, VAN Aken H, Brodde MF, Nofer JR, Kehrel BE. J Thromb Haemost. 2011 Nov;9(11):2278-90. doi: 10.1111/j.1538-7836.2011.04509.x.

• Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids.

Brodde MF, Korporaal SJ, Herminghaus G, Fobker M, Van Berkel TJ, Tietge UJ, Robenek H, Van Eck M, Kehrel BE, Nofer JR. Atherosclerosis. 2011 Apr;215(2):374-82. doi: 10.1016/j.atherosclerosis.2010.12.026.

• Markers of Blood Cell Activation and Complement Activation in Factor VIII and von Willebrand Factor Concentrates.

Brodde MF, Kehrel BE. Transfus Med Hemother. 2010;37(4):175-184.

• Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p.

Gunay-Aygun M, Zivony-Elboum Y, Gumruk F, Geiger D, Cetin M, Khayat M, Kleta R, Kfir N, Anikster Y, Chezar J, Arcos-Burgos M, Shalata A, Stanescu H, Manaster J, Arat M, Edwards H, Freiberg AS, Hart PS, Riney LC, Patzel K, Tanpaiboon P, Markello T, Huizing M, Maric I, Horne M, Kehrel BE, Jurk K, Hansen NF, Cherukuri PF, Jones M, Cruz P, Mullikin JC, Nurden A, White JG, Gahl WA, Falik-Zaccai T. Blood. 2010 Dec 2;116(23):4990-5001. doi: 10.1182/blood-2010-05-286534.

• Candida albicans and its metabolite gliotoxin inhibit platelet function via interaction with thiols.

Bertling A, Niemann S, Uekötter A, Fegeler W, Lass-Flörl C, von Eiff C, Kehrel BE. Thromb Haemost. 2010 Aug;104(2):270-8. doi: 10.1160/TH09-11-0769.

• Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis.

Jurk K, Ritter MA, Schriek C, Van Aken H, Droste DW, Ringelstein EB, Kehrel BE. Thromb Haemost. 2010 Jun;103(6):1193-202. doi: 10.1160/TH09-09-0620.

• High-density lipoproteins, platelets and the pathogenesis of atherosclerosis.

Nofer JR, Brodde MF, Kehrel BE. Clin Exp Pharmacol Physiol. 2010 Jul;37(7):726-35. doi: 10.1111/j.1440-1681.2010.05377.x. Review.

• Platelets: biochemistry and physiology. 

Kehrel BE. Hamostaseologie. 2008 Dec;28(5):289-98. Review.

• The role of platelets in haemostasis, thrombosis, immune defense and inflammation.

Jurk K, Kehrel BE. Dtsch Med Wochenschr. 2008 May;133(21):1130-5. doi: 10.1055/s-2008-1077228. Review.

• Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan.

Rennemeier C, Hammerschmidt S, Niemann S, Inamura S, Zähringer U, Kehrel BE. FASEB J. 2007 Oct;21(12):3118-32.

• Normal platelet reactivity in apolipoprotein E (apo E)-deficient mouse.

Nofer JR, Brodde M, Herminghaus G, Seedorf U, Assmann G, Kehrel BE. Platelets. 2006 Nov;17(7):498-500.